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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE4A
All Species:
9.7
Human Site:
Y286
Identified Species:
23.7
UniProt:
P27815
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P27815
NP_001104779.1
886
98143
Y286
S
G
N
Q
V
S
E
Y
I
S
T
T
F
L
D
Chimpanzee
Pan troglodytes
XP_001138439
809
91104
K253
L
Q
D
R
A
P
S
K
R
S
P
M
C
N
Q
Rhesus Macaque
Macaca mulatta
XP_001091940
721
82124
R165
L
A
S
L
R
S
V
R
N
N
F
T
I
L
T
Dog
Lupus familis
XP_536678
710
80315
N154
A
S
L
R
S
V
R
N
N
F
T
V
L
T
N
Cat
Felis silvestris
Mouse
Mus musculus
O89084
844
93539
Y281
S
G
N
Q
V
S
E
Y
I
S
N
T
F
L
D
Rat
Rattus norvegicus
P54748
844
93420
Y281
S
G
N
Q
V
S
E
Y
I
S
N
T
F
L
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088310
682
78201
A126
R
N
N
F
T
V
L
A
N
V
T
T
P
T
K
Zebra Danio
Brachydanio rerio
XP_700812
736
83987
T180
F
T
I
L
A
N
V
T
T
P
T
T
T
M
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W4S9
983
107322
F312
R
R
R
T
T
G
S
F
D
V
E
N
G
Q
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22000
674
75370
R118
S
S
S
V
H
A
R
R
E
S
F
L
Y
R
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
59
59.1
59.4
N.A.
81.9
81.8
N.A.
N.A.
N.A.
61.4
64.9
N.A.
47
N.A.
39
N.A.
Protein Similarity:
100
69.7
67.6
67
N.A.
86.9
86.3
N.A.
N.A.
N.A.
69.8
73.6
N.A.
57.9
N.A.
52.1
N.A.
P-Site Identity:
100
6.6
20
6.6
N.A.
93.3
93.3
N.A.
N.A.
N.A.
20
13.3
N.A.
0
N.A.
13.3
N.A.
P-Site Similarity:
100
20
33.3
26.6
N.A.
93.3
93.3
N.A.
N.A.
N.A.
20
26.6
N.A.
6.6
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
0
20
10
0
10
0
0
0
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
0
0
10
0
0
0
0
0
10
0
0
0
0
0
30
% D
% Glu:
0
0
0
0
0
0
30
0
10
0
10
0
0
0
0
% E
% Phe:
10
0
0
10
0
0
0
10
0
10
20
0
30
0
0
% F
% Gly:
0
30
0
0
0
10
0
0
0
0
0
0
10
0
10
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
0
30
0
0
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
10
% K
% Leu:
20
0
10
20
0
0
10
0
0
0
0
10
10
40
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% M
% Asn:
0
10
40
0
0
10
0
10
30
10
20
10
0
10
10
% N
% Pro:
0
0
0
0
0
10
0
0
0
10
10
0
10
0
0
% P
% Gln:
0
10
0
30
0
0
0
0
0
0
0
0
0
10
10
% Q
% Arg:
20
10
10
20
10
0
20
20
10
0
0
0
0
10
10
% R
% Ser:
40
20
20
0
10
40
20
0
0
50
0
0
0
0
0
% S
% Thr:
0
10
0
10
20
0
0
10
10
0
40
60
10
20
10
% T
% Val:
0
0
0
10
30
20
20
0
0
20
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
30
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _